The nearest airport is at Vagaikulam about 30 Kms. and the next nearest airport is Madurai about 140 Kms. away from Thoothukudi.
Thoothukudi is well connected by Rail also. Express trains to Chennai, Coimbatore and Mysore are operated daily by the Southern Railways. In addition to this, a passenger train is also operated between Thoothukudi to Tirunelveli daily. The Railway Station is located within the city limits.
Regular bus services are available from all important cities of Tamil Nadu and Kerala.